Oestrogen and a Goldilocks zone for post-damage muscle inflammation and repair?

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Point:Counterpoint: Estrogen and sex do/do not influence post-exercise indexes of muscle damage, inflammation, and repair POINT: ESTROGEN AND SEX DO INFLUENCE POST- EXERCISE INDEXES OF MUSCLE DAMAGE, INFLAMMATION, AND REPAIR

POINT: ESTROGEN AND SEX DO INFLUENCE POSTEXERCISE INDEXES OF MUSCLE DAMAGE, INFLAMMATION, AND REPAIR Estrogen and sex influences due to difference in estrogen exposure have been consistently reported to attenuate damage and/or inflammation and to accentuate repair in a variety of tissues and organs (4, 13, 22). Consistent with these findings, rodent models have provided compelling evidence of t...

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Comments on Point:Counterpoint: Estrogen and sex do/do not influence post-exercise indexes of muscle damage, inflammation, and repair.

TO THE EDITOR: Interpretations on the effect of estrogen/sex should be based on direct measures of muscle injury and subsequent repair/regeneration (i.e., improvements in muscle structure and function after injurious exercise). The inclusion of indexes of the inflammatory response (e.g., accumulation of neutrophils and/or macrophages) and inflammation (e.g., edema) into the discussion seems to ...

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Point:Counterpoint: Estrogen and sex do/do not influence post-exercise indexes of muscle damage, inflammation, and repair.

POINT: ESTROGEN AND SEX DO INFLUENCE POSTEXERCISE INDEXES OF MUSCLE DAMAGE, INFLAMMATION, AND REPAIR Estrogen and sex influences due to difference in estrogen exposure have been consistently reported to attenuate damage and/or inflammation and to accentuate repair in a variety of tissues and organs (4, 13, 22). Consistent with these findings, rodent models have provided compelling evidence of t...

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ژورنال

عنوان ژورنال: The Journal of Physiology

سال: 2018

ISSN: 0022-3751

DOI: 10.1113/jp276870